Figure 1.
Thyroid-responsive gene set is enriched with down-regulated genes in liver of obese humans. A, Heatmap showing liver expression of genes in different subcategories of the T3-regulated gene set (genes regulated by T3 in human skeletal muscle). Each column presents data for an individual subject, whereas each row represents an individual probe set. Expression values are colored by row-normalized values. Graphs demonstrate PCR verification of representative genes in liver of lean (open bars), obese (striped), and obese diabetic (black) subjects (mean ± sd). *, P < 0.05. Data for all genes are shown in Supplementary Table 2. B, Spearman correlation of liver fat content with expression of representative genes.