Table 2.
Association of adiposity measurements with ln leptin levels in the study subjects, stratified by gender
| Variables | Plasma ln leptin concentrations
|
|||||
|---|---|---|---|---|---|---|
| Males
|
Females
|
|||||
| Mean ± sd | β (se) | P value | Mean ± sd | β (se) | P value | |
| BMI quartiles | ||||||
| Q1 | 0.22 ± 0.58 | Reference | 1.44 ± 0.67 | Reference | ||
| Q2 | 0.28 ± 0.68 | 0.10 (0.08) | NS | 1.80 ± 0.57 | 0.33 (0.08) | <0.001 |
| Q3 | 0.29 ± 0.70 | 0.16 (0.09) | NS | 1.89 ± 0.82 | 0.40 (0.10) | <0.001 |
| Q4 | 0.75 ± 0.82 | 0.63 (0.11) | <0.001 | 2.39 ± 0.53 | 0.85 (0.09) | <0.001 |
| FMI quartiles | ||||||
| Q1 | −0.01 ± 0.61 | Reference | 1.43 ± 0.67 | Reference | ||
| Q2 | 0.20 ± 0.60 | 0.21 (0,08) | 0.012 | 1.68 ± 0.63 | 0.24 (0.08) | 0.003 |
| Q3 | 0.35 ± 0.58 | 0.35 (0,08) | <0.001 | 2.00 ± 0.60 | 0.50 (0.09) | <0.001 |
| Q4 | 1.02 ± 0.69 | 1.02 (0,09) | <0.001 | 2.40 ± 0.68 | 0.88 (0.09) | <0.001 |
| %BF quartiles | ||||||
| Q1 | −0.05 ± 0.65 | Reference | 1.44 ± 0.61 | Reference | ||
| Q2 | 0.18 ± 0.60 | 0.23 (0.08) | 0.006 | 1.72 ± 0.70 | 0.25 (0.08) | 0.003 |
| Q3 | 0.37 ± 0.52 | 0.41 (0.08) | <0.001 | 1.98 ± 0.62 | 0.48 (0.08) | <0.001 |
| Q4 | 1.04 ± 0.66 | 1.08 (0.09) | <0.001 | 2.38 ± 0.68 | 0.84 (0.09) | <0.001 |
| WC quartiles | ||||||
| Q1 | 0.15 ± 0.67 | Reference | 1.49 ± 0.64 | Reference | ||
| Q2 | 0.23 ± 0.64 | 0.14 (0.09) | NS | 1.72 ± 0.62 | 0.19 (0.09) | 0.024 |
| Q3 | 0.38 ± 0.59 | 0.30 (0.09) | <0.001 | 1.94 ± 0.77 | 0.40 (0.10) | <0.001 |
| Q4 | 0.79 ± 0.83 | 0.64 (0.10) | <0.001 | 2.37 ± 0.62 | 0.77 (0.09) | <0.001 |
| %TF quartiles | ||||||
| Q1 | 0.23 ± 0.61 | Reference | 1.60 ± 0.65 | Reference | ||
| Q2 | 0.35 ± 0.69 | 0.13 (0.08) | NS | 1.86 ± 0.70 | 0.19 (0.08) | 0.016 |
| Q3 | 0.37 ± 0.75 | 0.18 (0.09) | 0.049 | 1.95 ± 0.76 | 0.25 (0.08) | 0.003 |
| Q4 | 0.60 ± 0.81 | 0.43 (0.11) | <0.001 | 2.10 ± 0.75 | 0.38 (0.10) | <0.001 |
| Continuous variables | Partial R2 | β (se) | P value | Partial R2 | β (se) | P value |
| BMI | 0.178 | 0.16 (0.02) | <0.001 | 0.194 | 0.17 (0.01) | <0.001 |
| FMI | 0.374 | 0.41 (0.02) | <0.001 | 0.235 | 0.25 (0.02) | <0.001 |
| %BF | 0.397 | 0.09 (0.01) | <0.001 | 0.214 | 0.07 (0.01) | <0.001 |
| WC | 0.223 | 0.07 (0.01) | <0.001 | 0.176 | 0.06 (0.01) | <0.001 |
| %TF | 0.039 | 0.03 (0.01) | <0.001 | 0.030 | 0.03 (0.01) | <0.001 |
First quartile (Q1), second quartile (Q2), third quartile (Q3), and fourth quartile (Q4) were classified based on each 1-yr age- and gender-specific quartiles of body composition parameters. Generalized estimating equations were applied to compare the ln leptin differences between first quartile and other quartiles of adiposity variables. Partial R2s were calculated by comparing the multiple linear regression models with or without respective adiposity variables; the variables age and Tanner stages were included in the background model (without adiposity variables). NS, Non significant (P < 0.05).