Plasma glucose concentrations (d 2) at each glucose step in the studies with (▪, N+), and without (○, N−) coinfusion of naloxone on the previous day (d 1), C (▵), and C+ (×) studies. A, Hyperinsulinemic euglycemic clamp on d 1. B, Glucose infusion rates over time. *, P < 0.01.