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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: Cancer Res. 2009 Feb 10;69(4):1383–1391. doi: 10.1158/0008-5472.CAN-08-3612

Fig. 1. (A) EGF induces avβ5-mediated Rap1 activation and cell metastasis.

Fig. 1

(A) EGF treatment increased activity of Rac1 and Rap1 in FG cells plated on anti-β5, but not anti-β1, integrin antibodies. (B) Rap1 knockdown blocked EGF-induced cell migration on vitronectin but not fibronectin. (C) Knockdown of β5 expression blocked EGF-induced pulmonary metastasis, but not primary tumor weight, in the chick CAM model. Mean±SEM, n≥6, *p≤0.05.