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. 2009 Aug;1(2):a002543. doi: 10.1101/cshperspect.a002543

Figure 2.

Figure 2.

Domains of the desmosomal cadherins. Desmogleins (Dsg) and desmocollins (Dsc) contain four highly conserved extracellular (EC) domains, a more variable extracellular anchor (EA), a single transmembrane domain (TM), and an intracellular anchor (IA), which is followed by additional cytoplasmic domains. Desmocollin “a” isoforms and desmogleins contain an intracellular cadherin-like sequence (ICS) that binds plakoglobin. Desmogleins contain the additional intracellular proline-rich linker (IPL), a variable number of repeat unit domains (RUD), and a desmoglein terminal domain (DTD). The numbers of RUDs contained in each desmoglein isoform are as follows: Dsg 1, 5 repeats; Dsg 2, 6 repeats; Dsg 3, 2 repeats; and Dsg 4, 3 repeats.