Figure 4.

Armadillo protein family members. Plakoglobin (PG) contains 12-arm repeats that are flanked by distinct amino- and carboxy-termini. The plakophilins (PKP) contain 9-arm repeats with an insert between repeats 5 and 6 that introduces a bend into the overall structure. PKP1 and PKP2 exist as two isoforms, each generating a short “a” form and a longer “b” form, differing by the addition of 21 amino acids in arm repeat three (PKP1) and the addition of 44 amino acids in arm repeat four (PKP2).