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The arrangement of neocortical circuits and areas in the adult mouse brain. (A) The basic cortical circuit. Major extracortical inputs terminate in layer 4 and to a lesser degree in layer 6. Layer 4 neurons project to layers 2 and 3, which in turn innervate layers 5 and 6, the major output layers of the cortex. (B) Dorsal view of the adult mouse brain, with the functional roles of histologically defined areas labeled. Area maps redrawn from Wree et al. 1983.
