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. Author manuscript; available in PMC: 2009 Sep 11.
Published in final edited form as: Nature. 2008 Nov 26;456(7224):997–1000. doi: 10.1038/nature07541

Figure 1. NCoR-HDAC3 regulates peripheral clock and circadian physiology.

Figure 1

(a) Bmal1 expression in WT and DADm livers during ZT 7–9 (WT: n=6, DADm: n=4). (b) ChIP for acetylated histone H4 from WT and DADm livers at the Bmal1 RORE (n=3). (c) Bmal1 expression in immortalized mouse embryonic fibroblasts (MEFs) (n=3). (d) Bmal1 expression in MEFS after treatment with MS-275 (n=3). (e) Effect of Rev-erbα knockdown on MEF Rev-erbα and Bmal1 expression (n=3). (f) Bmal1 expression in MEFs following cell synchronization (fold difference relative to WT, time 0; n=3 per time point). (g) ChIP of acetylated histone H4 at the Bmal1 RORE following 50% serum shock. Mean +/− s.e.m of duplicate samples. Independent experiments gave similar results. (h) Voluntary locomotor wheel running activity, double plotted in each panel. (i) Average free running period (n=3). Three independent experiments gave similar results. Data are presented as mean +/− s.e.m. *p<0.05, **p<.01.