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. 2009 Sep 7;186(5):755–765. doi: 10.1083/jcb.200811058

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© 2009 Nguyen et al.

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Figure 5. — RGS2 residues involved in binding eIF2Bϵ and regulating protein synthesis. (A) Identity and location of RGS2 amino acids targeted for alanine substitution (yellow shading). (B) The effect of RGS2, RGS2-ala1, and RGS2-ala2 on luciferase protein synthesis as described in Materials and methods. The data are presented as mean ± SEM of three independent experiments performed in duplicate. *, P < 0.05 versus control (one-sample t test). (C) Interactions between monomeric eIF2Bϵ and wild-type RGS2, RGS2-ala1, and RGS2-ala2. The blots are representative of two independent experiments. IB, immunoblot. Molecular mass indicators are expressed in kilodaltons.