Correlation between hemodynamic indices and indexed LVM in individuals with aortic stenosis. (a–d) We observed little correlation between LVM and peak velocity across the aortic valve (Vmax) or indexed aortic valve area (AVAI), indices of aortic stenosis severity and hemodynamic pressure, in two independent cohorts of subjects with aortic stenosis characterized by echocardiography (a,b, n = 45) or cardiac MRI (c,d, n = 123), respectively. The percentage of variance of LVM accounted for by hemodynamic indices after including all significant covariates (R2) is indicated.