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Ability of VIP-CPT conjugates to elevate cAMP in MCF7 cells.
| Addition | cAMP, fmol |
|---|---|
| None | 7.0 ± 2.0 |
| VIP, 10 nM | 52.2 ± 6.0 |
| (A-NL-K)VIP, 1000 nM | 70.5 ± 7.2 |
| (A-NL-K)VIP-L2, 1000 nM | 58.3 ± 4.4 |
| (A-NL-K)VIP-L2-CPT, 1000 nM | 60.8 ± 7.3 |
| Forskolin, 50 uM | 76.3 ± 3.1 |
The agents were added to MCF7 cells for 5 min at 37°C. The mean value ± S.D. of 4 determinations each repeated in duplicate is indicated. This experiment is representative of 2 others
