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Two CT scans of the same patient, acquired at an interval of 4 months: (a) source scan and (b) target scan. Nodule A was identified by an experienced chest radiologist as marked by the box in each image. This is a small juxta-pleural nodule and there is apparently a significant location change between the two scans. Nodule A is one of the outliers that was misregistered in our study.
