Table 2.
Characteristics of HIV-infected patients during 306 admissions to the ICU at San Francisco General Hospital, 2000 - 2004, according to use of ART at the time of hospital admission
| Characteristic | All patients (n = 306) | No ART (n = 205) | ART (n = 101) | P-value |
|---|---|---|---|---|
| Age, years, mean (range) | 44 (24-72) | 43 (24-71) | 46 (25-72) | 0.65 |
| Gender*, n (%) | 0.078 | |||
| Male | 235 (79.7) | 152 (76.8) | 83 (85.6) | |
| Female | 60 (20.3) | 46 (23.2) | 14 (14.4) | |
| Race/ethnicity, n (%) | 0.30 | |||
| White | 125 (40.9) | 79 (38.5) | 46 (45.5) | |
| African American | 115 (37.6) | 77 (37.6) | 38 (37.6) | |
| Other/unknown | 66 (21.6) | 49 (23.9) | 17 (16.8) | |
| HIV risk factor, n (%) | 0.14 | |||
| Men who have sex with men | 54 (17.7) | 30 (14.6) | 24 (23.8) | |
| Users of injection drugs | 170 (55.6) | 118 (57.6) | 52 (51.5) | |
| Other/unknown | 82 (26.8) | 57 (27.8) | 25 (24.8) | |
| Medical history, n (%) | ||||
| History of prior opportunistic infection | 172 (57.7) | 104 (52.3) | 68 (68.7) | 0.007 |
| History of PCP | 63 (21.1) | 35 (17.6) | 28 (28.3) | 0.033 |
| History of malignancy | 39 (13.0) | 17 (8.5) | 22 (22.0) | 0.001 |
| PCP prophylaxis at time of admission | 141 (46.5) | 69 (33.8) | 71 (72.7) | <0.001 |
| Clinical data | ||||
| CD4 count†, cells/ul, median (IQR) | 109 (211) | 95 (213) | 141 (198) | 0.021 |
| HIV viral load‡, copies/ml, mean log (SD) | 4.47 (1.72) | 4.81 (0.97) | 3.71 (1.37) | <0.001 |
| Albumin§, g/dl, mean (SD) | 2.7 (0.8) | 2.6 (0.8) | 2.9 (0.9) | 0.006 |
| LDH∥, U/L, median (IQR) | 320 (288) | 352 (304) | 449 (223) | 0.087 |
| APACHE II score**, median (IQR) | 22 (14) | 22 (12) | 22 (16) | 0.34 |
| Mechanical ventilation, n (%) | 205 (67.7) | 143 (70.1) | 62 (62.6) | 0.19 |
| AIDS-associated admission diagnosis, n (%) | 63 (20.6) | 51 (24.9) | 12 (11.9) | 0.008 |
| PCP diagnosis, n (%) | 42 (13.8) | 39 (19.0) | 3 (3.0) | <0.001 |
| Admission diagnosis, n (%) | ||||
| Respiratory failure | 130 (42.3) | 90 (43.9) | 40 (39.6) | |
| Sepsis | 62 (20.3) | 45 (22.0) | 17 (16.8) | |
| Neurologic | 50 (16.3) | 34 (16.6) | 16 (15.8) | |
| Other | 64 (21.1) | 36 (17.6) | 28 (27.7) | |
| Survival, n (%) | 212 (69.3) | 144 (70.2) | 68 (67.3) | 0.70 |
Definition of abbreviations: AIDS = acquired immunodeficiency virus; APACHE = Acute Physiology and Chronic Health Evaluation; ART = highly active antiretroviral therapy; HIV = human immunodeficiency virus; ICU = intensive care unit; IQR = interquartile range; LDH = lactate dehydrogenase; n = number; PCP = Pneumocystis pneumonia.
Legend: Five transgender patients were excluded from gender-stratified analysis.
Data were available for 265 admissions.
Data were available for 211 admissions.
Data were available for 273 admissions.
Data were available for 184 admissions.
Data were available for 261 admissions.