Effects of commercial MnTBAP, pure MnTBAP, and MnTE-2-PyP on carrageenan-induced pleural exudate production, accumulation of polymorphonuclear cells in pleural cavity and myeloperoxidase activity (MPO). A significant production in pleural exudate (A), polymorphonuclear and (B) cells infiltration was observed in pleural cavity from vehicle-treated mice at 4h after carrageenan administration. Furthermore, MPO activity in lung tissues was significantly elevated at 4 h after carrageenan administration in vehicle-treated mice (C). The treatment with commercial or pure MnTBAP, and MnTE-2-PyP significantly reduced the presence of pleural exudate (A) and the number of inflammatory cells (B) as well as lung tissue levels of MPO (C). Data are means ± SEM of 10 mice for each group. *p < 0.01 vs. SHAM; °p < 0.01 vs. carrageenan group.