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. 2009 Jul 14;18(19):3684–3695. doi: 10.1093/hmg/ddp316

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Figure 5. — SBDS has distinct functions in translation and cellular responses to stress. Inhibition of RNA Polymerase I using Actinomycin D had no effect on (A) phosphorylation of p53 or (B) cleavage of Caspase 3 following UV irradiation of HEK293 cells. Inhibition of translation using (C) cycloheximide or (D) puromycin reduces cleavage of Caspase 3 and phosphorylation of p53 following UV irradiation in HEK293 cells. (E) Overexpression of HA-Sbds decreases global translation (left panel) but does not influence Caspase 3 cleavage or p53 phosphorylation following UV irradiation in HEK293 cells (right panel).