Table 1.

Anti-HCV activity and cytotoxicity of the four compounds used singly in HCV-replicon-containing Huh-7 cells (Clone B)

Compound	EC50*	EC90*	CC50†
2′-C-MeC, μM	2.4±0.8	8.8±1.9	>33
2′-F-C-MeC, μM	1.2±0.8	3.8±1.7	>33
IFN-α2b, IU/ml	0.5±0.6	17±12	>99
RBV, μM	8.0±3.8	NM‡	19±6.1

All values represent the average of four to six experiments and samples were performed in duplicate ± SD.

^*EC₅₀ and EC₉₀ effective concentrations required for reducing hepatitis C virus (HCV) levels by 50% and 90%, respectively, on day 5;

^†CC₅₀, cytotoxicity concentration required for reducing the rRNA levels by 50% on day 5.

^‡Not measurable (NM) because activity at this level was similar to its toxicity. IFN, interferon; RBV, ribavirin.