Table 1.
Statistically Significant Changes in Protein Expression
| Proteins Changed with Drug Administration that DO NOT PERSIST following 100 days of abstinence | Change at 1 day | |
|---|---|---|
| Fold Change | P-value (t-test) | |
| Alpha-enolase | −1.15 | 0.011 |
| Alpha-internexin | +1.16 | 0.005 |
| Gamma-actin | +1.20 | 0.01 |
| Heat shock protein 73 | +1.32 | 0.030 |
| Neurofilament medium polypeptide | +1.20 | 0.012 |
| Proteins Changed with Drug Administration that PERSIST following 100 days of abstinence | Change | |||
|---|---|---|---|---|
| at 1 day | at 100 days | |||
| Fold Change | P-value (t-test) | Fold Change | P-value (t-test) | |
| Alpha-internexin | +1.16 | 0.005 | +1.10 | 0.020 |
| Creatine kinase | +1.23 | 0.010 | +1.10 | 0.049 |
| Dihydropyrimidase related protein-2 (DRP-2) | +1.14 | 0.015 | +1.35 | 0.003 |
| H+ transporting ATPase | −1.11 | 0.014 | −1.13 | 0.005 |
| Phosphatidylethanolamine-binding protein (PEBP) | +1.10 | 0.030 | +1.10 | 0.014 |
| Similar to capping protein beta subunit | −1.11 | 0.034 | −1.18 | 0.013 |
| Proteins UNCHANGED with Drug Administration and CHANGED BY ASTINENCE | Change at 100 days | |
|---|---|---|
| Fold Change | P-value (t-test) | |
| ATP synthase beta subunit | +1.18 | 0.004 |
| Dynamin-1 | −1.34 | 0.035 |
| Glyoxylase domain-containing protein 4 | −1.21 | 0.0076 |
| Malate dehydrogenase 1 | −1.21 | 0.039 |
| SNAP-25B | −1.20 | 0.031 |
| Tumor protein, translationally-controlled 1 | −1.11 | 0.012 |
All proteins shown have ANOVA p<0.05