Fig. 3.

Proteome-wide prediction of directional protein interactions from the integrated human protein interaction dataset. A, the proportion of directional protein interactions in all human interactions. PDPPI, predicted directional PPIs; KDPPI, known directional PPIs in signaling databases; and VDPPI, verified directional PPIs, which are the overlaps of PDPPI and KDPPI. B, the human DPIN predicted by the method. According to the PIDSs, the inferred directional protein interactions are marked with different colors. The protein interactions with 10 > |PIDS| ≥ 2 are marked with blue and one line widths, and those of |PIDS| ≥ 10 with red and two widths. These figures are drawn by Pajek software (31). C, comparison of the PIDS distribution in human PPI training set and DPIN.