Table 3.

Characteristics of Kidney injury molecule-1 (Kim-1)^*

Parameters	Description
Other names	Hepatitis A virus cellular receptor-1 (HAVCR-1), T cell immunoglobulin like molecule-1 (TIM-1), cochlear injury molecule-1 (CIM-1)
Chromosomal location	Human (5q31), chimpanzee (5), rat (10q21), mouse (11B1.1)
Molecular mass	Human (359 aa), chimpanzee (predicted: 357 aa), rat (307 aa), mouse (305 aa)
Structure	Immunoglobulin domain, threonine-serine-proline-rich mucin domain, transmembrane domain, short cytoplasmic tail
Number of KIM-1 homologues	Human (three: KIM-1, KIM-3, KIM-4), rat (six: Kim-1 to Kim-6), mouse (eight: Kim-1 to Kim-8)
% Identity of human KIM-1 protein	Chimpanzee (79%), rat (39%), mouse (37%)
Upregulation in kidney injury/toxicity/dedifferentiation models	Adriamycin-nephrosis	Ischemia/reperfusion
	Brain dead donor rat kidney	Kidney fibrosis
	Cadmium	Mercuric chloride
	Chromium	Ochratoxin
	Cisplatin	Polycystic kidney disease
	Cyclosporine	Protein-overload
	Endotoxin	Renal cell carcinoma
	Folic acid	Sevoflurane
	Gentamicin	S-(1,1,2,2-tetrafluoroethyl)-l-cysteine (TFEC)

^*Adapted and modified from Vaidya and Bonventre, 2006 (27).