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. Author manuscript; available in PMC: 2010 Mar 31.
Published in final edited form as: Circulation. 2009 Mar 16;119(12):1592–1600. doi: 10.1161/CIRCULATIONAHA.108.838268

Table 2. Cross-sectional correlates (multivariable linear regression) of ADMA, L-arginine, and the Arg/ADMA ratio.

Variable Unit of Increase/Categories Regression Coefficient P Value
ADMA
Age 10 year 0.02 <0.0001
BMI 1 unit 0.002 <0.0001
Diastolic blood pressure 10 mm Hg -0.007 0.0044
Smoking Smoker vs. non-smoker 0.015 0.0137
L-Arginine
Age 10 year 1.113 0.0054
Sex Male vs. female 2.946 <0.0001
BMI 1 unit -0.170 0.0166
Diabetes Present vs. absent -4.933 <0.0001
Smoking Smoker vs. non-smoker 3.848 0.0002
Alcohol consumption Drinks/week -0.260 0.0117
eGFR 1 unit 0.037 0.0180
Arg/ADMA Ratio
Age year -4.921 <0.0001
Sex Male vs. female 3.606 0.0242
BMI 1 unit -0.845 <0.0001
Diabetes Present vs. absent -5.205 0.0387
Alcohol consumption Drinks/week -0.689 0.0019

Independent variables reported are those that remained in the model after stepwise backward elimination analysis and were statistically significant in the final model (p<0.05). Independent variables were chosen on the basis of significant univariate associations and pathophysiological mechanisms. R2 of the final model was 0.0347 for ADMA, 0.0179 for L-arginine, 0.0247 for the Arg/ADMA ratio.

BMI denotes body mass index. eGFR denotes estimated glomerular filtration rate.