Table 3. Biomarkers and CVD Risk.

	Number of Events/number at risk (%)	Unadjusted Hazard Ratio (95% CI)	p	Multivariable-adjusted Hazard Ratio (95%CI)*	p
ADMA
ADMA (per SD increase)		1.00 (0.90-1.12)	0.94	0.92 (0.82, 1.05)	0.21
Quartile 1	54/754 (7.2)	Referent	-	Referent	-
Quartile 2	63/746 (8.5)	1.19 (0.83-1.71)	0. 35	1.05 (0.70-1.55)	0.83
Quartile 3	87/744 (11.7)	1.34 (0.95-1.88)	0.10	1.17 (0.80-1.70)	0.42
Quartile 4	77/712 (10.8)	1.00 (0.71-1.42)	0.998	0.85 (0.58-1.25)	0.41
Trend		1.00 (0.90-1.11)	0.97	0.96 (0.85-1.08)	0.47
L-arginine
L-Arg (per SD increase)		1.01 (0.91-1.12)	0.85	0.99 (0.87-1.11)	0.83
Quartile 1	57/727 (7.8)	Referent	-	Referent	-
Quartile 2	65/757 (8.6)	1.26 (0.88-1.79)	0.21	1.25 (0.85-1.83)	0.26
Quartile 3	82/753 (10.9)	1.17 (0.84-1.65)	0.35	1.04 (0.72-1.51)	0.84
Quartile 4	77/719 (10.7)	1.12 (0.80-1.58)	0.52	0.95 (0.65-1.38)	0.77
Trend		1.02 (0.92-1.14)	0.66	0.97 (0.86-1.09)	0.56
Arg/ADMA
Arg/ADMA (per SD increase)		0.98 (0.88-1.09)	0.70	1.01 (0.91-1.14)	0.80
Quartile 1	74/725 (10.2)	Referent		referent
Quartile 2	63/730 (8.6)	0.94 (0.67-1.32)	0.72	0.94 (0.64-1.37)	0.74
Quartile 3	77/752 (10.2)	1.07 (0.78-1.48)	0.66	1.10 (0.77-1.56)	0.60
Quartile 4	67/749 (9.0)	0.99 (0.71-1.38)	0.96	1.17 (0.81-1.69)	0.40
Trend		1.01 (0.91-1.12)	0.84	1.06 (0.95-1.20)	0.30

^*adjusted for age, sex, systolic and diastolic BP, hypertension treatment, smoking, diabetes, total/HDL cholesterol, creatinine, log-BNP and log-UACR. N=2,544 for the multivariable adjusted model. Mean (SD) was 0.54 (0.13) μmol/l for ADMA, 78.8 (20.8) μmol/l for L-arginine, and 149.8 (44.6) for the Arg/ADMA ratio.