Table 4. Biomarkers and Mortality Risk.

	Number of Events/number at risk (%)	Unadjusted Hazards Ratio (95% CI)	p	Multivariable-adjusted Hazards Ratio (95%CI)*	p
ADMA
ADMA (per SD increase)		1.10 (0.99-1.22)	0.09	1.21 (1.07-1.37)	0.003
Quartile 1	50/832 (6.0)	Referent	-	Referent	-
Quartile 2	61/827 (7.4)	1.23 (0.85-1.79)	0.27	1. 08 (0.71-1.64)	0.71
Quartile 3	79/834 (9.5)	1.38 (0.97-1.97)	0.07	1.15 (0.77-1.71)	0.51
Quartile 4	95/827 (11.5)	1.33 (0.95-1.88)	0.10	1.53 (1.05-2.23)	0.03
Trend		1.09 (0.98-1.21)	0.08	1.15 (1.02-1.30)	0.02
L-arginine
L-Arg (per SD increase)		0.87 (0.77-0.98)	0.02	0.89 (0.77-1.02)	0.08
Quartile 1	71/821 (8.7)	Referent	-	Referent	-
Quartile 2	64/833 (7.7)	1.03 (0.73-1.44)	0.88	0.96 (0.66-1.41)	0.85
Quartile 3	88/850 (10.4)	0.98 (0.71-1.34)	0.88	0.86 (0.60-1.24)	0.43
Quartile 4	62/816 (7.6)	0.70 (0.50-0.98)	0.04	0.73 (0.50-1.07)	0.10
Trend		0.90 (0.81-0.997)	0.04	0.90 (0.80-1.02)	0.09
Arg/ADMA
Arg/ADMA (per SD increase)		0.82 (0.72-0.94)	0.003	0.80 (0.69-0.93)	0.004
Quartile 1	92/824 (11.2)	Referent	-	Referent	-
Quartile 2	77/827 (9.3)	0.85 (0.63-1.15)	0.30	0.76 (0.53-1.07)	0.12
Quartile 3	70/835 (8.4)	0.85 (0.62-1.16)	0.30	0.69 (0.48-1.01)	0.05
Quartile 4	46/834 (5.5)	0.52 (0.36-0.74)	0.0003	0.49 (0.33-0.74)	0.0007
Trend		0.83 (0.75-0.93)	0.0006	0.80 (0.71-0.91)	0.0007

^*adjusted for age, sex, systolic and diastolic BP, hypertension treatment, smoking, diabetes, total/HDL cholesterol, creatinine, prevalent CVD, and logBNP, log renin, log Hcy, log UACR, and log CRP. N=2,750 for the multivariable adjusted model. Mean (SD) was 0.55 (0.13) μmol/l for ADMA, 78.9 (20.7) μmol/l for L-arginine, and 149.4 (44.4) for the Arg/ADMA ratio.