Table 5a. ADMA and Mortality Risk in Participants with Diabetes versus those without Diabetes.

	No. events/no. at risk (%)	Unadjusted Hazards Ratio (95% CI)	p	Multivariable-adjusted Hazards Ratio (95%CI)*	p
Subjects with no Diabetes (n=2,948)
ADMA (per SD increase)		1.16 (1.03-1.31)	0.02	1.30 (1.13-1.50)	0.0002
Quartile 1	36/746 (4.8)	Referent		Referent	-
Quartile 2	41/737 (5.6)	1.16 (0.74-1.82)	0.51	1.04 (0.63-1.73)	0.88
Quartile 3	62/736 (8.4)	1.62 (1.07-2.44)	0.02	1.44 (0.90-2.31)	0.12
Quartile 4	77/729 (10.6)	1.45 (0.97-2.15)	0.07	1.75 (1.13-2.72)	0.01
Trend		1.14 (1.01-1.28)	0.04	1.23 (1.07-1.41)	0.004
Subjects with Diabetes (n=372)
ADMA (per SD increase)		0.92 (0.74-1.15)	0.47	0.85 (0.62-1.16)	0.30
Quartile 1	14/86 (16.3)	Referent		Referent	-
Quartile 2	20/90 (22.2)	1.25 (0.63-2.49)	0.52	0.84 (0.37-1.91)	0.68
Quartile 3	17/98 (17.4)	0.83 (0.41-1.69)	0.61	0.44 (0.18-1.07)	0.07
Quartile 4	18/98 (18.4)	0.98 (0.48-1.97)	0.94	0.71 (0.30-1.71)	0.45
Trend		0.95 (0.76-1.18)	0.62	0.84 (0.63-1.12)	0.24

^*adjusted for age, sex, systolic and diastolic BP, hypertension treatment, smoking, total/HDL cholesterol, creatinine, prevalent CVD, logBNP, log renin, log Hcy, log UACR, and log CRP.

SD in Subjects with no Diabetes: ADMA=0.13

SD in Subjects with Diabetes: ADMA=0.13