Table 5b. L-Arginine/ADMA Ratio and Mortality Risk in Participants with Diabetes versus those without Diabetes.

	No. events/no. at risk (%)	Unadjusted Hazards Ratio (95% CI)	p	Multivariable-adjusted Hazards Ratio (95%CI)*	p
Subjects with no Diabetes (n=2,948)
ARG/ADMA (per SD increase)		0.77 (0.66-0.90)	0.0009	0.72 (0.60-0.87)	0.0005
Quartile 1	66/697 (9.5)	Referent		Referent	-
Quartile 2	62/735 (8.4)	0.86 (0.61-1.22)	0.40	0.68 (0.45-1.02)	0.06
Quartile 3	57/765 (7.5)	0.86 (0.60-1.22)	0.39	0.66 (0.43-1.00)	0.05
Quartile 4	31/751 (4.1)	0.43 (0.28-0.67)	0.0001	0.37 (0.23-0.62)	0.0001
Trend		0.80 (0.71-0.90)	0.0003	0.75 (0.65-0.87)	0.0002
Subjects with Diabetes (n=372)
ARG/ADMA (per SD increase)		0.99 (0.80-1.22)	0.91	1.07 (0.82-1.40)	0.62
Quartile 1	26/127(20.5)	Referent		Referent	-
Quartile 2	15/92 (16.3)	0.77 (0.41-1.46)	0.42	0.79 (0.35-1.75)	0.56
Quartile 3	13/70 (18.6)	0.87 (0.44-1.70)	0.67	0.59 (0.24-1.45)	0.25
Quartile 4	15/83 (18.1)	0.90 (0.48-1.71)	0.75	0.97 (0.43-2.16)	0.93
Trend		0.97 (0.79-1.19)	0.76	0.95 (0.73-1.24)	0.71

^*adjusted for age, sex, systolic and diastolic BP, hypertension treatment, smoking, total/HDL cholesterol, creatinine, prevalent CVD, logBNP, log renin, log Hcy, log UACR, and log CRP.

SD in Subjects with no Diabetes: Arg/ADMA=43.77

SD in Subjects with Diabetes: Arg/ADMA=48.20