Table 1.
Study | Inclusion criteria
|
No of vessels (% successful dilatation) | Complications related to PTCA in intervention groups | Follow up (months) | Pre-existing condition (%)
|
Mean ejection fraction (%) | Trial quality score* | ||
---|---|---|---|---|---|---|---|---|---|
Clinical | Angiographic | MI | Non-Q MI | ||||||
Parisi 199217 | Stable angina, history of angina, MI within 3 months, exercise test with ST depression >3 mm, no previous PTCA | Single or serial stenosis within same artery 70% to 99% proximal two thirds | 1 (82) | CABG (2.0%); MI (1.0%); non-Q wave MI (3.0%) | 6 | 0 | 28.8 | 65 | 4 |
Sievers 199316 | Previous non-Q wave MI, no angina in daily life, no previous Q wave MI | Mean (SD) degree of stenosis: 86% (11) | 1 (100) | None | 24 | 0 | 54.5 | NA | 2 |
MASS 199518 | Stable angina, no Q wave MI, no left ventricular dysfunction | Stenosis ⩾80% before first diagonal branch, length <12 mm, no total occluded lesion | 1 (96) | CABG (2.8%); MI (2.8%) | 30 | 0 | 0 | 76 | 3 |
Folland 199713 | Stable angina, history of angina, MI within 3 months, exercise test with ST depression >3 mm, no previous PTCA | Stenosis ⩾70% proximal two thirds, no main artery stenosis >50%, no 3 vessel disease | 2 (69) | CABG (2%); MI (0.01%); non-Q wave MI (3.0%) | 57 | 59 | NA | 66 | 2 |
RITA-2 199714 | Angina leading to admission within 90 days, previous Q wave MI, no previous PTCA, no left main stem disease | Stenosis ⩾50% stenosis in two projections or 70% stenosis in one projection or occluded arteries | 1-3 (93) | CABG (1.4%); MI (1.4%); death (0.2%) | 32 | 47 | NA | Normal function in 54% of patients | 4 |
AVERT 199915 | Angina or asymptomatic, MI or unstable angina but not within 14 days, no triple vessel disease | Stenosis ⩾50% in one or two vessels, no main artery stenosis | 2 (99) | MI (0.5%) | 18 | 43† | 61 | 4 |
See methods section for details of scoring.
Figure for MI and non-Q wave MI.
MI: myocardial infarction, CABG: coronary artery bypass graft; NA: not available.