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. Author manuscript; available in PMC: 2009 Sep 11.
Published in final edited form as: Biol Psychiatry. 2008 Jul 18;64(8):691–700. doi: 10.1016/j.biopsych.2008.06.003

Figure 4.

Figure 4

(A) Ventral tegmental area (VTA) overexpression of GFP, IRS2, or AKT in nonstressed mice does not significantly alter ambulatory locomotor hyperactivity or habituation over a 1-hour beam break locomotor test [virus main effect, F(4,43) = 1.44, p > .2]. Overall locomotor activity was also comparable across viral groups (inset). (B) VTA overexpression of GFP, IRS2, or AKT in nonstressed mice does not alter baseline social interaction rates [virus × target interaction, F(4,43) = .98, p > .3], as well as (C) levels of BDNF in the nucleus accumbens measured 3 days after viral overexpression [F(4,33) = .32, p > .5]. AKT, thymoma viral proto-oncogene; BDNF, brain-derived neurotrophic factor; GFP, green fluorescent protein; HSV, herpes simplex virus.