Table 3.

Clinicopathologic features of EVN with t(1;19) and 1p19q co‐deletion. Abbreviations: EVN = extraventricular neurocytomas; GTR = gross total resection; HPF = high‐powerfields; IHC = immunohistochemistry; ISH = in situ hybridization; MIB‐1 = mindbomb homolog‐1; NA = data not available; NED = no evidence of disease; STR = subtotal resection.

Case	Age/sex	Location	Diagnosis	Histology	Mitoses/ 10 HPF	IHC	Surgery	Treatment	Follow‐up
1	51/F	Left parietal lobe	Atypical EVN	Calcification; palisading necrosis; apoptotic bodies; vascular hypertrophy. No infiltration.	3	Synaptophysin+	STR	External beam radiation and Temodar®	NED 20 Mo postoperative
2	52/F	Left parieto‐occipital lobe	Atypical EVN	Vascular hypertrophy. No infiltration.	5	Synaptophysin+ Chromogranin+ (IHC and ISH) Neu‐N + (focal) MIB‐1 labeling index × 20%	GTR	Craniospinal radiation (54 Gy to tumor bed) and multiple chemotherapies with recurrences including temozolamide most recently	Expired 5.5 years after resection, after at least three recurrences
3	67/F	Right frontal lobe	Atypical EVN	Rosettes, ganglionic maturation, increased apoptosis. No infiltration.	4	Synaptophysin+ Neurofilament+	STR	Radiation: 50 Gy	Recurrence; expired 3.5 years after resection
4	39/F	Temporal lobe	Well‐differentiated EVN	Rosettes. No infiltration.	0	Synaptophysin+	NA	NA	Recurrence