Computed changes in configurational entropy versus changes in mean energy Δ(U +W), for βCD with ferrocene derivatives (blue stars), designed RGD receptors9 (blue circles), aqueous cyclodextrins with various guests8 (blue “x”s), various host-guest systems in chloroform6 (blue “+”s), CB[7] with ferrocene derivatives (red diamonds), and CB[7] with bicyclo[2.2.2]octane derivatives (black squares).