Figure 2. FCRL6 is expressed by effector and effector memory CD8⁺ T cells and cytotoxic CD4⁺ T cells.

(A) CD8^bright cells from adult blood were gated and the FCRL6⁺ cells, highlighted in black, plotted against CD45RA vs CCR7 and CD27 vs CCR7 expression. Total CD8⁺ T cells are labeled grey in the dotplots. In the CD45RA/CCR7 plot, naive (N), central memory (CM), effector memory (EM), and effector (E) CD8⁺ T cells are distinguished as previously described [22]. (B) Gated adult blood CD3⁺CD8^bright cells were analyzed for FCRL6 and perforin expression as in Figure 1. (C) FCRL6⁺CD4⁺ T cells from one of three representative donors are gated and highlighted in black. This subset was further analyzed for perforin, CD57, NKG2D, CD45RA, and CCR7 expression. Total CD4⁺ T cells are labeled grey in the dotplots.