Table 4. Allelic distributions of the V16A variant reported by earlier studies.

Study group	Kimura et al.		Gotoh et al.
Subjects	Case	Control	Case	Control
Number of subjects	99	197	215	363
Genotype (%)
TT	59.6	67.5	81.9	73.8
TC	31.3	31.5	18.1	23.4
CC	9.1	1.0	0	2.8
Minor allele frequency (%)	24.7	16.8	9.1	14.5
Allelic P-value	0.020	-	0.0073	-

The genotype data in Table 3 refer to descriptions made by Kimura et al. [37] and Gotoh et al. [35]. Minor allele frequency of the V16A variant in case subjects were widely divergent; much higher frequency of the variant allele was observed in the Kimura et al.’s study.