Table 2. Association between genotype distributions of CHRM1 polymorphisms and individuals with high myopia.
|
Polymorphisms |
Individuals with myopia > 6.0D (%) |
Individuals with myopia < 0.5D (%) |
OR |
95% CI* |
p value#/Cp-value## |
|
rs11823728
(S1) | |||||
| G/G |
187 (96.3) |
106 (97.2) |
1 |
- |
0.74/2.96 |
| A/G |
6 (3.1) |
3 (2.8) |
1.13 |
0.28–4.63 |
|
| A/A |
1 (0.5) |
0 (0) |
- |
||
|
rs544978
(S2) | |||||
| G/G |
145 (74.7) |
76 (69.7) |
1 |
- |
5.99×10−7/2.40× 10−6 |
| A/G |
46 (23.7) |
14 (12.8) |
1.72 |
0.89–3.33 |
|
| A/A |
3 (1.5) |
19 (17.4) |
0.08 |
0.02–0.29 |
|
|
rs2186410
(S3) | |||||
| A/A |
150 (77.3) |
89 (81.7) |
1 |
- |
0.03/0.12 |
| A/G |
24 (12.3) |
4 (3.7) |
3.56 |
1.2–10.59 |
|
| G/G |
20 (10.3) |
16 (14.7) |
0.74 |
0.37–1.51 |
|
|
rs542269
(S4) | |||||
| A/A |
149 (76.8) |
91 (83.5) |
1 |
- |
5.96×10−9/2.38×10−8 |
| A/G |
43 (22.2) |
3 (2.8) |
8.75 |
2.64–29.04 |
|
| G/G | 2 (1.0) | 15 (13.8) | 0.08 | 0.02–0.36 | |
Genotype frequencies were compared between individuals with myopia greater than 6.00 D and less than 0.5 D. The asterisk indicates CI=confidence interval. #The χ2 test or Fisher's exact test was performed to obtain the p value. It was considered statistically significant if p was less than 0.05. ##Cp-value, p-value corrected by Bonferroni correction.