Table 3. Association between allelic frequencies of CHRM1 polymorphisms and individuals with high myopia.
|
Alleles |
Individuals with myopia > 6.0D (%) |
Individuals with myopia < −0.5D (%) |
OR |
95% CI* |
p value#/Cp-value## |
|
rs11823728 | |||||
| G |
380 (97.9) |
215 (98.6) |
1 |
0.544/2.176 |
|
| A |
8 (2.0) |
3 (1.4) |
1.51 |
0.4–5.75 |
|
|
rs544978 | |||||
| G |
336 (86.6) |
166 (76.1) |
1 |
|
0.001/0.004 |
| A |
52 (13.4) |
52 (23.9) |
0.49 |
0.32–0.76 |
|
|
rs2186410 | |||||
| A |
324 (83.5) |
182 (83.5) |
1 |
|
0.995/3.98 |
| G |
64 (16.5) |
36 (16.5) |
1 |
0.64–1.56 |
|
|
rs542269 | |||||
| A |
341 (87.9) |
185 (84.9) |
1 |
|
0.291/1.164 |
| G | 47 (12.1) | 33 (15.1) | 0.77 | 0.48–1.25 | |
The frequencies of alleles were compared between individuals with myopia greater than 6.00 D and less than 0.5 D. The asterisk indicates CI=confidence interval. #The χ2 test or Fisher's exact test was performed to obtain the p value. It was considered statistically significant if p was less than 0.05. ##Cp-value, p value corrected by Bonferroni correction.