Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Sep 8;15:1806–1818.

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Cellular localization of the p.L54P, p.N48K and WT CLRN1-HA polypeptides. The transfected BHK-21 cells were immunostained with HA antibody (red) showing the localization of WT CLRN1-HA (E), the novel sequence alteration p.L54P mutated CLRN1-HA (B) and the known disease-causing p.N48K mutated CLRN1-HA (H). The same cells were immunostained with plasma membrane –specific antibody (green) in panels A, D, and G. Double-staining shows that WT CLRN1-HA (F) and the p.L54P mutated CLRN1-HA (C) colocalize (yellow) with the plasma membrane marker whereas the known mutation p.N48K (I) does not colocalize with the plasma membrane marker. Cells were viewed with a confocal immunofluorescence microscope. Scale bar represents 10 µm.