Figure 7. DCPIP inhibits tumor growth in a human A375 melanoma SCID-mouse xenograft model.

Human A375 melanoma cells (10 × 10⁶) were implanted s.c. into the right flank of SCID mice. 17 days after cell injection animals were pair-matched (65 mm³ average tumor size) and one day later (vertical arrow) daily treatment (DCPIP: low dose group: 4 mg/kg/d, 100 µl, q.d., n=12; high dose group: 16 mg/kg/d, 200 µl, b.i.d., n=11) was initiated by intraperitoneal injection as specified in Materials and Methods. Control animals (n=12) received PBS only. (A) Tumor growth curves were obtained by determining average tumor volumes until day 30 after cell injection. Data points are depicted as means ± SEM and statistical comparison between individual data points was performed using the two-sided Student’s t test (*, p < 0.05; **, p < 0.01; ***, p < 0.001). (B) Mean body weight was monitored during the duration of the experiment and expressed as % change from the average weight obtained on the day of pairmatching.