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. Author manuscript; available in PMC: 2009 Sep 14.
Published in final edited form as: Biochem Pharmacol. 2008 Mar 6;75(11):2204–2213. doi: 10.1016/j.bcp.2008.02.030

Fig. 4.

Fig. 4

Redundant role of RXRs in mediating 9-cis-RA-induced activation of tk-(3A4)3-Luc. HepG2 cells were transiently transfected with the hVDR expression plasmids (50 ng), hRXRα (50 ng), the tk-(3A4)3-Luc reporter construct (300 ng), and the renilla luciferase expression vector (10 ng). Cells were treated with the indicated retinoids (10 μM) or DMSO (0.1%) for 48 h and then assayed for luciferase activity. The results are expressed as relative fold changes of luciferase activity to DMSO control. Each value represents the mean ± SD of three independent experiments. Comparison was performed between each group: *p < 0.05, RXRα compared to VDR, #p < 0.05, RXRα compared to RXRα/VDR, † p < 0.05, VDR compared to RXRα/VDR.