Table 4.
Mean (95% confidence interval) BMD and aBMC values for individuals segregated by genotype for the N740N (rs2306862) and V1119V (rs556442) polymorphisms in exons 10 and 15, respectively
Spine | SNP | Genotype | Model 1 | Model 2 |
---|---|---|---|---|
BMD | N740N | TT | 0.78 (0.77–0.79) | 0.78 (0.77–0.79) |
TC | 0.77 (0.76–0.78) | 0.76 (0.75–0.77) | ||
CC | 0.75 (0.73–0.78) | 0.74 (0.71–0.76) | ||
aBMC | N740N | TT | 78.7 (77.9–79.5) | 79.0 (77.9–80.0) |
TC | 77.7 (76.7–78.8) | 76.6 (75.2–77.9) | ||
CC | 76.7 (74.5–78.9) | 74.2 (71.5–76.9) | ||
aBMC | V1119V | GG | 79.2 (78.2–80.2) | 79.1 (77.9–80.4) |
GA | 78.3 (77.5–79.2) | 77.9 (76.9–79.0) | ||
AA | 77.4 (75.8–79.1) | 76.7 (74.7–78.7) |
Values shown are adjusted for age at time of DXA scan and gender (n = 479, model 1) or adjusted for age, gender, pubertal status, height, and weight (n = 239 stage I and stage II only, model 2)