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Immunohistochemical demonstration of somatostatin receptor2a (SSTR2a) in the GHoma (A), silent GHoma (B) and TSHoma (C). Note the distinct staining of SSTR2a on the cell membrane of many tumor cells. These tumor cells are expected to respond to somatostatin analogue treatment. The bottom scheme (D) demonstrates Pit-1 binding site in the promoter region of the mouse Sstr2 gene (modified from Olias G et al.) [18].
