Table 1.
Pituitary related transcription factors in development
| Transcription Factor | Related Hormone | Predicted Function |
|---|---|---|
| PTX1 | ACTH, LH/FSH/GH, PRL, TSH | Important for early pituitary development and later activation of hormone gene |
| PROP1 | GH, PRL, TSH, LH/FSH | Important for somatotrope, lactotrope, thyrotrope and gonadotrope development |
| FOXL2 | αSU, | Express in early pituitary and related to differentiation of αSU positive cells |
| EGR1 | LH/FSH | Important in gonadotrope and somatotrope development |
| NEUROD1 | ACTH | Important in POMC gene regulation in corticotropes |
| TPIT | ACTH | Important for POMC gene expression in the corticotrope and melanotrope |
| PIT1 | GH, PRL, TSH | Need for somatotrope, lactotrope and thyrotrope development |
| GATA2 | LH/FSH, TSH | Regulation of gonadotrope and thyrotrope cell differentiation |
| SF1 | LH/FSH | Required for gonadotrope development |
| ERα | PRL | Important in PRL and gonadotropin gene expression and lactotrope cell growth |
| GHRH-R | GH | Regulation of somatotrope differentiation |
Modified from Savage et al. 2003 [28].