TABLE 3.
BASELINE AND 1-MONTH SEROTYPE-SPECIFIC GEOMETRIC MEAN IgG ANTIBODY LEVELS
| Baseline IgG μg/ml (95% CI)
|
1-Month IgG μg/ml (95% CI)
|
|||
|---|---|---|---|---|
| Serotype | PCV7 | PPSV23 | PCV7 | PPSV23 |
| 4 | 0.26 (0.17–0.38) | 0.32 (0.23–0.44) | 2.03 (1.24–3.32) | 0.70 (0.47–1.03) |
| 6B | 0.90 (0.65–1.25) | 0.85 (0.67–1.08) | 2.96 (1.96–4.48) | 1.76 (1.23–2.52) |
| 9V | 0.86 (0.61–1.20) | 0.76 (0.55–1.06) | 4.69 (3.27–6.74) | 2.09 (1.47–2.97) |
| 14 | 2.88 (1.86–4.46) | 2.90 (1.96–4.27) | 17.2 (11.7–25.3) | 11.22 (7.42–16.96) |
| 18C | 1.26 (0.84–1.89) | 1.17 (0.83–1.64) | 9.26 (6.29–13.6) | 3.70 (2.58–5.29) |
| 19F | 3.20 (2.43–4.21) | 3.16 (2.55–3.93) | 7.33 (5.16–10.4) | 6.20 (4.75–8.09) |
| 23F | 0.75 (0.52–1.07) | 0.55 (0.40– 0.76) | 7.31 (4.56–11.7) | 1.52 (0.99–2.32) |
Definition of abbreviations: OPK = opsonophagocytosis killing index; PCV7 = 7-valent diphtheria-conjugated pneumococcal polysaccharide vaccine; PPSV23 = 23-valent pneumococcal polysaccharide vaccine.
Within each study group, postvaccination antibody levels and OPK were higher than baseline (P < 0.01) for all serotypes. Bolded items represent a significant difference in absolute postvaccination IgG levels between vaccine groups and underlined items represent a significant difference in 1 month to baseline IgG ratio.