TABLE 4.

UNIVARIATE AND MULTIVARIATE ASSOCIATIONS BETWEEN AGE, SEX, FEV₁ % PREDICTED, PRIOR VACCINATION STATUS, AND VACCINE ASSIGNMENT AND IMMUNE RESPONSE

	Univariate		Multivariate
	Estimate (95% CI)	P Value	Estimate (95% CI)	P Value
PCV7	1.25 (0.44, 2.06)	0.003	1.31 (0.58, 2.05)	0.001
Age (per 10 yr)	−0.84 (−1.23, −0.44)	<0.001	−0.66 (−1.06, −0.27)	0.001
Previously vaccinated	−1.37 (−2.17, −0.57)	0.001	−1.07 (−1.87, −0.28)	0.009
FEV1, % predicted	−0.01 (−0.04, 0.01)	0.36	−0.02 (−0.04, 0.01)	0.13
Female sex	−0.38 (−1.24, 0.48)	0.38	−0.04 (−0.80, 0.72)	0.91

Definition of abbreviations: CI = confidence interval; OPK = opsonophagocytosis killing index; PCV7 = 7-valent diphtheria-conjugated pneumococcal polysaccharide vaccine.

Immune response was assessed as the number of serotypes to which each subject exhibited a 10-fold increase in OPK.