Fig. 5.

The effect of tetracaine on Ca²⁺ signaling in airway SMCs induced by MCh. High-frequency Ca²⁺ oscillations induced in airway SMCs by 200 nM MCh were either slowed by 10 μM tetracaine (A) or stopped by 50 μM tetracaine (B, bottom). The line-scan plot (B, top) shows that the cessation of the Ca²⁺ oscillations (white vertical lines) is associated with the relaxation of the SMC (upward deflection of oscillation trace). The resumption of the Ca²⁺ oscillation is correlated with the recontraction of the SMC. Representative data are from 4 different slices from 3 mice.