Skip to main content
. 2009 Jun 5;297(2):L299–L308. doi: 10.1152/ajplung.00008.2009

Fig. 8.

Fig. 8.

Conceptual model of RA-induced reseptation and the role of FGF in the induction of αSMA in a PDGFRα-positive progenitor cell. RA induces proliferation after 14 days, and after 18 days the number of low lipid and PDGFRα-positive cells (green) increases. Based on Lindahl's and McGowan's data (24, 35), we propose that the PDGFRα-positive cell, which is low in lipids, is a precursor cell for the interstitial myofibroblast and requires FGF signaling to induce expression of αSMA. Our data show that in the presence of FGF signaling, PDGFRα-positive cells induce αSMA (red) expression and that expression of dnFGFR inhibits induction of αSMA in PDGFRα-positive cells, resulting in a block of myofibroblast differentiation and increase of PDGFRα-positive cells.