Table 2.
Blood gases, MPAP, AoP, LAP, HR, and Hct at baseline and at maximal response after brief infusion of cinaciguat and ACh into the left pulmonary artery catheter
| Baseline | Cinaciguat (5.0 μg) | ACh (15.0 μg) | |
|---|---|---|---|
| pH | 7.37±0.01 | 7.33±0.01 | 7.36±0.01 |
| Pco2, Torr | 47.8±2.1 | 49.5±1.6 | 45.3±1.4 |
| Po2, Torr | 19.6±0.9 | 18.8±1.3 | 20.9±1.1 |
| O2 saturation, % | 48.5±5.0 | 44.1±4.5 | 52.1±4.6 |
| MPAP, mmHg | 43.9±3.6 | 39.8±2.9 | 42.1±2.1 |
| AoP, mmHg | 46.0±5.0 | 41.2±4.3 | 38.1±1.6 |
| LAP, mmHg | 2.3±0.2 | 2.0±0.2 | 1.9±0.2 |
| HR, beats/min | 166.6±8.0 | 182.1±8.5 | 171.1±5.1 |
| Hct, % | 33.0±1.9 | 29.1±1.6 | 30.4±1.3 |
Values are means ± SE. MPAP, main pulmonary artery pressure. Cinaciguat and ACh were infused into the left pulmonary artery catheter at 0.3 ml/min for 10 min.