Fig. 3.

Hypoxia induces increases in mRNA levels of cytokines and receptors that may control the recruitment of cells in rat PAs. A and B: distribution of the log-transformed relative expression levels of cytokines (A) and their receptors (B) in PAs isolated by laser capture microdissection (LCM) from hypoxic animals (dark gray) and regression animals (light gray). Bars represent the 25th and 75th percentiles, and whiskers designate 1.5 interquartile ranges. The lines between measurements connect the median values. Stars above the dark gray bars indicate significant deviation of the mean values from the reference line at 0. Stars above the 2- and 28-day regression time points (light gray bars) relate to significant differences between the means for those time points and the 28-day hypoxic values. *P = 0.01–0.05, **P < 0.01. SDF-1, stromal cell-derived factor-1; MCP-1, monocyte chemoattractant protein-1.