Fig. 4.

Hypoxia induces increases in mRNA levels of genes that may control the adhesion, differentiation, and growth of cells in rat PAs. A–C: distribution of the log-transformed relative expression levels of adhesion molecules (A), cell differentiation molecules (B), and growth factors (C) in PAs isolated by LCM from hypoxic animals (dark gray) and regression animals (light gray). Bars represent the 25th and 75th percentiles, and whiskers designate 1.5 interquartile ranges. The lines between measurements connect the median values. Stars above the dark gray bars indicate significant deviation of the mean values from the reference line at 0. Stars above the 28- and 2-day regression time points (light gray bars) relate to the significant difference between the means for those 2 time points and the 28-day hypoxic values. *P = 0.01–0.05, **P < 0.01. TGF-β₁, transforming growth factor-β₁.