Table 3.

Gene expression levels of cytokines in rat PAs, lung parenchyma, and aortic arch

	Gene	PA		Parenchyma		Aortic Arch
1 Day (n = 7)		28 Days (n = 10)	1 Day (n = 3)	28 Days (n = 4)	1 Day (n = 1)	28 Days (n = 1)
Chemokines and receptors	C5	0.35±0.62	1.39±0.32	−0.57±0.41	−0.10±0.08	−0.26	—
	CCL2/MCP-1	−0.07±0.37	1.44±0.23	0.11±1.66	1.19±0.29	−0.17	0.38
	CXCL12/SDF-1	0.52±0.19	1.26±0.12	0.53±0.47	−0.29±0.32	0.04	0.26
	CXCR4	1.82±0.32	1.19±0.26	0.45±0.18	−0.18±0.12	0.02	−0.09
	FIZZ-1	0.54±0.43	0.16±0.35	−0.72±0.24	−0.06±0.20	−0.16	0.02
	IL-6	−0.30±0.41	2.45±0.50	−1.35±0.54	−0.81	−0.33	0.32
	IL-6R	−0.36±0.29	1.34±0.55	−1.18±0.74	0.13±0.22	−0.20	0.56
Adhesion molecule	Osteopontin	0.71±0.33	1.39±0.23	0.61±1.23	1.71±0.07	—	—
Cell differentiation	Endothelin-1	0.77±0.29	0.53±0.14	0.01±0.27	0.10±0.15	0.03	0.29
	TGF-β1	1.07±0.16	1.04±0.22	0.17±0.14	−0.01±0.16	−0.10	−0.03
Fibrosis-associated protein	HSP-47	0.88±0.23	−0.52±0.33	0.75±0.18	−0.18±0.15	−0.07	−0.40

Values are log inverse mean fold changes ± SE for PA (n = 10) and parenchyma (n = 4). Results are pooled from n = 4 animals for aortic arch samples. Renal artery samples showed similar gene expression as the aortic arch (data not shown). —, Missing values due to mRNA levels too low to calculate fold change accurately or undetectable via RT-PCR.