Table 1.
Biodistribution and organ targeting indices of 125I-J120
|
%ID/g |
SOA | TTI | TSI | ||
|---|---|---|---|---|---|
| J120 | mIgG1 | ||||
| Lung | 29.1 | 0.6 | 48.5 | 72.8 | 230.4 |
| Liver | 0.2 | 0.4 | 0.5 | 0.5 | 2.4 |
| Heart | 1.7 | 0.4 | 4.3 | 4.3 | 20.2 |
| Brain | 0 | 0 | 0.0 | 0.0 | 0.0 |
| Kidney | 1.2 | 0.3 | 4.0 | 3.0 | 19.0 |
| Spleen | 0.2 | 0.8 | 0.3 | 0.5 | 1.2 |
| Bone | 0.1 | 0.2 | 0.5 | 0.3 | 2.4 |
| Stomach | 0.3 | 0.5 | 0.6 | 0.8 | 2.9 |
| Esophagus | 0.4 | 0.3 | 1.3 | 1.0 | 6.3 |
| Colon | 0.8 | 0.2 | 4.0 | 2.0 | 19.0 |
| Pancreas | 0.3 | 0.2 | 1.5 | 0.8 | 7.1 |
| Muscle | 0.1 | 0.1 | 1.0 | 0.3 | 4.8 |
| Skin | 0.2 | 0.3 | 0.7 | 0.5 | 3.2 |
| Blood | 0.4 | 1.9 | 0.2 | 1.0 | 1.0 |
SOA, specific organ ammumulation (ratio of J120 to control IgG in each organ; TTI, tissue targeting index (antibody in tissue/g of tissue/antibody in blood/g of blood); TSI, tissue selectivity index (TTI for J120/TTI for control IgG.