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AR42J cells also require sharp increases in cytosolic calcium for induction of apoptosis. AR42J cells were loaded with 25 nm TMRM-AM and 10 μm Fluo-4-AM (A and B). Fluorescence was measured over time before and after application of 30 μm menadione in cells pretreated with 10 μm thapsigargin (A, n = 6) or 200 nm thapsigargin followed by 10 μm thapsigargin (B, n = 6). Changes in TMRM fluorescence after menadione treatment were compared in C (mean ± S.E., *, p < 0.05).
