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. 2009 Sep 29;3(9):e522. doi: 10.1371/journal.pntd.0000522

Figure 3. Splenomegaly in infected mice.

Figure 3

Although expansion of B- and T-cells is the major cause of splenomegaly in wild-type animals, SCID BEIGE mice infected with B. recurrentis A17 displayed significant (p<0.01) splenomegaly,which indicates a T-, B-, and NK-cell-independent immune response.