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. 2009 Sep 23;4(9):e7144. doi: 10.1371/journal.pone.0007144

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Milo et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A – Antisense oligonucleotides used to knock down expression of gata3 led to simultaneous loss of p27^kip1 protein. B–D – These images are from the same group of cells. dnGata3 (green label in B) led to cytoplasmic localisation of p27^kip1 (labelled in red) and loss from the nucleus (C,D). E – In cells transfected with dngata3 the levels of p27^kip1 protein were significantly lower (p<0.0001). This result correlated with a decrease in expression of p27^kip1 (cdkn1b) following treatment with siRNA to gata3 (Table 4).